
Sean and Christian operate on identical twin sisters, who request surgery to look different from one another. Sean tries to encourage Liz (Roma Maffia) to return to work. Matt worries about sex with his girlfriend Vanessa (guest star Kate Mara) and her possible reaction to his foreskin, leading him to self-circumcision.

Julia attempts to create direction in her life, and comes to terms with her recent actions. Christian's feelings for Julia begin to affect his sex life. Grace Santiago, both professionally and personally. McNamara/Troy's new on-site psychologist (guest star Kevin Chamberlin) creates conflict between Sean and Christian, while at the same time Sean grows interested in an independent shrink, Dr. Guest starring Ruth Williamson and Roma Maffia. Aspiring model Kimber (guest star Kelly Carlson), the latest in a long line of Christian's conquests, discovers the ugly truth about his womanizing. Sean's son Matt goes to Christian when requesting a circumcision. Sean's wife Julia struggles at home with her lingering feelings for Christian, stemming from a one-night stand they had together while in college. With the exception of the pilot, each episode is named after the character(s) that are scheduled to have plastic surgery.Best friends since college, Sean McNamara and Christian Troy run a successful plastic surgery practice in Miami, but Christian's unethical acceptance of $300,000 from a mobster desperate for a new face threatens both their friendship and their business. The series ran for 100 episodes, concluding with the series finale on March 3, 2010. Accordingly, the second half of the fifth season was not screened until January 6, 2009, in the U.S. The fifth season premiered on October 30, 2007, though production was affected by the 2007 Writers Strike.

While the show was initially set in Miami, at the end of the fourth season, the practice was relocated to Los Angeles and many of the characters followed.
The show began in July 2003 and concluded with the end of the sixth season in March 2010. Each episode typically involves the cosmetic procedures of one or more patients, and also features the personal and professional lives of its main cast. Christian Troy (portrayed by Dylan Walsh and Julian McMahon respectively). The series focuses on "McNamara/Troy", a plastic surgery practice, and follows its founders, Dr. Nip/Tuck is an American medical drama created by Ryan Murphy, which aired on FX in the United States between 20.
